Pharmabuzz

ORPHAN DRUGS Orphan drugs are those drugs the pharmaceutical and other biotech companies are constantly researching and developing new medications to treat a rare medical condition, the condition itself is referred to as an Orphan disease . The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development . Orphan Disease: A rare disease is also referred to as an “ Orphan Disease ”, is any disease which affects a small percentage of the population. Most of the rare diseases are genetic in nature,so these are present in a person throughout in his/her life,even if the symptoms do not appear immediately. Many rare diseases appear early in life, and about 30 percent of children with rare diseases will die before reaching their fifth birthday. A rare disease occurs in less than 200,

DRUG INFORMATION ABOUT EXENATIDE Exenatide is an injectable diabetes medicine that helps control blood sugar levels. This medication helps your pancreas produce insulin more efficiently. Exenatide is used to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used in combination with exenatide if needed. Prounciation: ex-N-a-tide Class: Antidiabetic agent, Incretin mimetic agent Trade name: Byetta – Injection Dosage available: solution 5 mcg/dose - Injection,                             solution   10 mcg/dose- Injection. Pharmacology: Glucagon-like peptide-1 agonist that enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon. SIDE EFFECTS OF EXENATIDE: For Consumers All medicines may cause side effects, but many people have no, or minor, side effects. Most COMMON side effects persist or become bothersome when using Exenatide: o       Constipation; decreased appetite; diarrhea; dizziness; feeling jittery

  THREE NEW DRUGS FOR TYPE 2 DIABETES Patients’ suffering from type 2 diabetes mellitus requires metformin plus something which will help to reduce the cardiovascular risk factors are some of the common aims of the drug therapy. However, the progressive impairment of both the secretion and action of insulin in the condition mean that high blood glucose concentrations usually worsen over time, so necessitating escalation of hypoglycaemic therapy. Three drugs in two new classes that act on the hormonal regulation of insulin secretion have been launched recently. They are:   (1) exenatide (Byetta – Eli Lilly)                   (2) sitagliptin (Januvia – MSD).                   (3) vildagliptin (Galvus – Novartis).

Why Cancer does not affect the Heart???? o       Heart cancers do occur, but very rarely cancer is in the abnormal, uncontrolled proliferation of cells, usually fatal. o       In general, tumors may be malignant (cancerous)-rapidly fatal if untreated or benign-causes relatively little harm. o       Cancer in any organ can be primary, originating in that organ itself or secondary when it has spread to other parts of the body. Secondary is either direct when it spreads by contiguity or indirect when the spread is through lymphatic or blood. o       Thus heart cancer (primary cardiac tumor) is cancer that arises in the heart. Cancerous tumor begin in the heart are more often sarcomas, a type of cancer that originates in the soft tissues of the body. o       The vast majority of heart tumors are benign; they include myxomas, myomas and fibromas. o       Although heart cancers are rare, mostly found to be secondary, having come from some where else. o       These include lymphomas that ori